Pfam Domain Function Thyroid Hormone Receptor, alpha (THRA) (AA 1-490) protein (His tag) Protein. In addition, they play critical roles in the development of organisms. Thyroid hormone receptors (TR) are members of the nuclear receptor superfamily. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. "Thyroid Hormone Receptors alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Amongst the most important functions of thyroid hormone receptors are regulation of metabolism and heart rate. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. Herein, we have develo … Background Many physiological effects of thyroid hormone (TH) are mediated by its canonical action via nuclear receptors (thyroid hormone receptor α and β, TRα, TRβ) to regulate transcription of target genes. Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. There are at least two TR isoforms, TRalpha and TRbeta, which act as mediators of thyroid hormone in tissues. ... Thyroid Hormone Receptor Alpha Structure. However, the relative expression of each TR isoform in target tissues is still elusive. Recombinant Human Thyroid Hormone Receptor alpha 1 protein is an Escherichia coli Full length protein, > 95% purity and validated in FuncS, SDS-PAGE. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. Isoforms [edit | edit source] There are three forms of the thyroid hormone receptor designated alpha-1, beta-1 and beta-2 that are able to bind thyroid hormone. Thyroid hormones exert their effects through alpha (TRα1) and beta (TRβ1 and TRβ2) receptors. Thyroid hormone receptor-beta resistance has been associated with metabolic traits. The aim of this study was to assess the prognostic value of the steroid hormone receptor expression, counting the retinoid X receptor (RXR) and thyroid hormone receptors (THRs), on the two different breast cancer (BC) entities: multifocal/multicentric versus unifocal. THRA Origin: Human Source: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Protein target information for Thyroid hormone receptor alpha (human).