People. NR4A3 Immunohistochemistry Lacks Sensitivity for the Diagnosis of Extraskeletal Myxoid Chondrosarcoma. FOIA Acinic cell carcinoma is a malignant tumor representing 2% of all salivary tumors. Menu. Acinic cell carcinoma (AciCC) harbors a recurrent t(4;9)(q13;q31) translocation, which leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3). AbstractAcinic cell carcinoma (AciCC) harbors a recurrent t(4;9)(q13;q31) translocation, which leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3). 90% of the time found in the parotid gland, 10% intraorally on buccal mucosa or palate. Acinic cell carcinoma (AciCC) harbors a recurrent t(4;9)(q13;q31) translocation, which leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3). Careers. Organisations. A gradual mass progression of the terminal end of the parotid gland usually affected. Mueller SA, Gauthier MA, Blackburn J, Grady JP, Kraitsek S, Hajdu E, Dettmer MS, Dahlstrom JE, Lee CS, Luk PP, Yu B, Giger R, Kummerfeld S, Clark JR, Gupta R, Cowley MJ. Previous work on tissue microarrays suggests that NR4A3 immunohistochemistry (IHC) may be useful in the diagnosis of AciCC. The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer. Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands Buy Article: $62.00 + tax ( Refund Policy ) Ectopic ACTH Production and Cushing's Syndrome in a Patient with Parotid Acinic Cell Carcinoma with High-Grade Transformation: Tumor Context and Clinical Implications. Background: Acinic cell carcinoma (AcCC) is diagnostically challenging on fine-needle aspiration because it can mimic several other neoplasms or even normal acinar tissue. The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas. 1 The diagnosis of AcCC by fine‐needle aspiration (FNA) is often challenging. Previous work on tissue microarrays suggests that NR4A3 immunohistochemistry (IHC) may be useful in … This site needs JavaScript to work properly. Thus far, only a single study has evaluated the utility of NR4A3 immunohistochemistry (IHC) in the diagnosis of AciCC, using a tissue microarray to assess most non-AciCC tumor types. Recently, we discovered the recurrent genomic rearrangement [t(4;9)(q13;q31)] enabling upregulation of the transcription factor Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) through enhancer hijacking as the oncogenic driver event in acinic cell carcinoma (AciCC) of the salivary glands. Nuclear NR4A3 immunostaining is a specific and sensitive novel marker for acinic cell carcinoma of the salivary glands Am J Surg Pathol , 43 ( 2019 ) , pp. Abstract: Acinic cell carcinoma (AcCC) is a morphologically distinctive salivary gland malignancy often associated with chromosome rearrangements leading to overexpression of the NR4A3 transcription factor. Acinic cell carcinoma of the salivary gland (ACC-SG) is characterized by a recurrent chromosomal rearrangement (t(4; 9)(q13; q31)) that upregulates the transcription factor NR4A3. Arch Pathol Lab Med. Acinic cell carcinoma (AcCC) is diagnostically challenging on fine‐needle aspiration because it can mimic several other neoplasms or even normal acinar tissue. Rearrangements of NR4A3 occur in more than 80% of extraskeletal myxoid chondrosarcoma (EMC) as well as in salivary acinic cell carcinoma (AciCC), driving tumorigenesis. However, little is known about how NR4A3 contributes to AcCC biology. Recently, we discovered the recurrent genomic rearrangement [t(4;9)(q13;q31)] enabling upregulation of the transcription factor Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) through enhancer hijacking as the oncogenic driver event in acinic cell carcinoma (AciCC) of the salivary glands. KEY WORDS: acinic cell carcinoma; cytology; DOG1; nuclear receptor subfamily 4 group A member 3 (NR4A3); salivary gland. 2013 Jul;21(4):283-6. doi: 10.1097/PAI.0b013e31826a277e. ACC of … NR4A3 Immunohistochemistry Reliably Discriminates Acinic Cell Carcinoma from Mimics Authors (first, second and last of 4) Kristine S. Wong; Adrian Mariño-Enriquez; Vickie Y. Jo; Content type: Original Paper; Published: 10 September 2020 IHC detected NR4A3 expression in all cases of recurrent/metastatic AciCC and tumors with high grade transformation. Research Projects. Fetched: February 24th, 2021, ... Acinic cell carcinoma(ACC)is an invasive malignancy primarily characterized by proliferation of tumor cells that resemble acinar cells of the salivary glands and pancreas. Acinic cell carcinoma (AcCC) is the second most common malignant neoplasm of the salivary glands, is located most commonly in the parotid gland, and derives from the acinar epithelium. Firefox version 24 or greater For versions 24-26, TLS 1.2 is disabled by default so you will need to enable it in the browser settings if this hasn’t already been done. Skaugen JM, Seethala RR, Chiosea SI, Landau MS. Cancer Cytopathol. Acinic Cell Carcinoma is a low-grade neoplasm occurs on the epithelial cell lining of the salivary gland. Awards. 2019 Sep;43(9):1264-1272. doi: 10.1097/PAS.0000000000001279. Two PA and two PAC showed multifocal expression of NR4A3 in more than 5% of cells, of weak intensity in 3 cases and moderate in 1 PAC, yielding an overall specificity of 97% for NR4A3 IHC for the diagnosis of AciCC. Thus far, only a single study has evaluated the utility of NR4A3 immunohistochemistry (IHC) in … NR4A3 induces endothelial dysfunction through up-regulation of endothelial 1 expression in adipose tissue-derived stromal cells. Saluja K, Ravishankar S, Ferrarotto R, Zhu H, Pytynia KB, El-Naggar AK. With EMC, NR4A3 rearrangements fuse the 3’ end of NR4A3, including its DNA binding domain, to a variety of 5’ oncogenic transcription activator fusion partners. Background: Acinic cell carcinoma (AcCC) is diagnostically challenging on fine-needle aspiration because it can mimic several other neoplasms or even normal acinar tissue.Immunopositivity for DOG1, especially circumferential membranous staining, can support the diagnosis of AcCC but is not entirely specific, and it is prone to technical and interpretive challenges on small specimens. Bethesda, MD 20894, Copyright Detailed Previous work on tissue microarrays suggests that NR4A3 immunohistochemistry (IHC) may be useful in the diagnosis of AciCC. In the current study, we evaluated the usefulness of NR4A3 immunostaining and NR4A3 fluorescence in situ hybridization (FISH) in the differential diagnosis of AciCC, comparing a total of 64 AciCCs including 17% cases with high-grade transformation, 29 secretory (mammary analog) carcinomas (MASC), and 70 other salivary gland carcinomas. Epub 2013 Jul 3. Privacy, Help Objective: To investigate the diagnostic role of NR4A3/NOR-1 immunohistochemistry in acinic cell carcinoma (AciCC) of the salivary gland. 1264 - 1272 CrossRef View Record in Scopus Google Scholar We conclude that NR4A3 is upregulated through enhancer hijacking and has important oncogenic functions in AciCC. Am J Surg Pathol. Acinic cell carcinoma is an uncommon low-grade malignant tumor of the salivary glands, in which some cells resemble normal acinic cells. Salivary gland-like tumors of the breast express basal-type immunohistochemical markers. Evaluation of NR4A3 immunohistochemistry (IHC) and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma. List of Publication » Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands Home. These tumours are similar to normal salivary gland tissue and occur most frequently in the parotid gland. At scanning power, basophillia and prominent lymphoid infiltrate should raise suspicion of acinic cell carcinoma Tumor shows multidirectional differentiation towards acinar, ductal as well as myoepithelial elements Some tumor cells must demonstrate differentiation towards acinar cells None of the MASCs or other salivary gland carcinomas displayed any nuclear NR4A3 immunostaining. Mod Pathol. Haller F, Skálová A, Ihrler S, Märkl B, Bieg M, Moskalev EA, Erber R, Blank S, Winkelmann C, Hebele S, Baněčková M, Wiemann S, Müller S, Zenk J, Eils R, Iro H, Hartmann A, Agaimy A. Would you like email updates of new search results? 2013 Jul;7 Suppl 1(Suppl 1):S30-6. Careers. Previous work on tissue microarrays suggests that NR4A3 immunohistochemistry … Introduction. 2019 Jan 21;10(1):368. doi: 10.1038/s41467-018-08069-x. Clipboard, Search History, and several other advanced features are temporarily unavailable. Herein we evaluate the diagnostic performance of NR4A3 IHC for AciCC in a large cohort of 157 salivary gland tumors, using whole tissue sections. Previous work on tissue microarrays suggests that NR4A3 immunohistochemistry (IHC) may be useful in the diagnosis of AciCC. Epub 2020 Aug 18. Unable to load your collection due to an error, Unable to load your delegates due to an error. Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands. 2021 Feb;129(2):104-113. doi: 10.1002/cncy.22338. Prevention and treatment information (HHS). These tumors are similar to normal salivary gland tissue and occur most frequently in the parotid gland. Publications. https://orcid.org. Acinic cell carcinoma; FISH; IHC; NR4A3; Salivary gland; Secretory carcinoma. Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity. The cohort consisted of 37 AciCC (6 of them (16%) with high grade transformation), 30 secretory carcinomas (SC), and 90 additional salivary gland tumors, including mucoepidermoid carcinomas (MEC), polymorphous adenocarcinomas (PAC), pleomorphic adenomas (PA), salivary duct carcinomas (SDC), and adenoid cystic carcinomas (AdCC). Mol Cancer Res. Nguyen L, Chopra S, Laskar DB, Rao J, Lieu D, Chung F, Kim ED, de Peralta-Venturina M, Bose S, Balzer B. Hum Pathol. Mol Cancer Res. Clipboard, Search History, and several other advanced features are temporarily unavailable. National Library of Medicine Head Neck Pathol. Europe PMC. Expression of NR4A3/NOR-1 in acinic cell carcinoma of the salivary gland. In conclusion, NR4A3 is a highly sensitive and specific immunohistochemical marker for AciCC; moderate to strong and/or diffuse NR4A3 expression is a consistent and diagnostic feature of AciCC. [Expression of NR4A3/NOR-1 in acinic cell carcinoma of the salivary gland]. Recently, we discovered the recurrent genomic rearrangement [t(4;9)(q13;q31)] enabling upregulation of the transcription factor Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) through enhancer hijacking as the oncogenic driver event in acinic cell carcinoma (AciCC) of the salivary glands. Acinic cell carcinoma (AcCC) is a morphologically distinctive salivary gland malignancy often associated with chromosome rearrangements leading to overexpression of the NR4A3 transcription factor. Here the authors perform genomic, transcriptomic and epigenomic profiling of AciCC and find highly recurrent and specific rearrangements [t(4;9)(q13;q31)], which lead to enhancer hijacking that activates oncogenic transcription factor NR4A3 8600 Rockville Pike 2021 Feb;19(2):180-191. doi: 10.1158/1541-7786.MCR-20-0707. 1,2 Women are affected more often than men, and the age at occurrence is earlier than in other salivary gland cancers. Unable to load your collection due to an error, Unable to load your delegates due to an error. 1264 - 1272 CrossRef View Record in Scopus Google Scholar Please enable it to take advantage of the complete set of features! 2020 Nov 8;49(11):1142-1146. doi: 10.3760/cma.j.cn112151-20200224-00127. Immunopositivity for DOG1, 2 Most cases are unilateral, and bilateral involvement has rarely been reported. NR4A3 induces endothelial dysfunction through up-regulation of endothelial 1 expression in adipose tissue-derived stromal cells. However, little is known about how NR4A3 contributes to AcCC biology. Acinic cell carcinoma (AciCC) harbors a recurrent t(4;9)(q13;q31) translocation, which leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3). Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A. Haller F, Bieg M, Will R, Körner C, Weichenhan D, Bott A, Ishaque N, Lutsik P, Moskalev EA, Mueller SK, Bähr M, Woerner A, Kaiser B, Scherl C, Haderlein M, Kleinheinz K, Fietkau R, Iro H, Eils R, Hartmann A, Plass C, Wiemann S, Agaimy A. Nat Commun. doi: 10.1007/s12105-013-0455-y. 2019 Dec;43(12):1726-1728. doi: 10.1097/PAS.0000000000001346. NR4A3 nuclear staining by IHC was considered positive if present in more than 5% of tumor cells. 1. Acinic cell carcinoma (AciCC) harbors a recurrent t(4;9)(q13;q31) translocation, which leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3). FOIA Lee DY, Brayer KJ, Mitani Y, Burns EA, Rao PH, Bell D, Williams MD, Ferrarotto R, Pytynia KB, El-Naggar AK, Ness SA. COVID-19 is an emerging, rapidly evolving situation. 2020 Nov 08;49(11):1142-1146 Authors: Cheng K, Wang X, Wei X, Ma J, Xia QY, Shi QL, Zhou XJ, Rao Q Abstract Objective: To investigate the diagnostic role of NR4A3/NOR-1 immunohistochemistry in acinic cell carcinoma (AciCC) of the salivary gland. Acinic cell carcinoma (AciCC) is a rare salivary gland carcinoma that is poorly understood. Cheng K, Wang X, Wei X, Ma J, Xia QY, Shi QL, Zhou XJ, Rao Q. Zhonghua Bing Li Xue Za Zhi. Vargas AC, Maclean FM, Bonar F, Mahar A, Gill AJ. Am J Surg Pathol. INTRODUCTION Acinic cell carcinoma (AcCC) is the second most common malignant neoplasm of the salivary glands, is located most commonly in the parotid gland, and derives from the acinar epithelium.1 The diagnosis of AcCC by Overall, 92% of AciCC (34/37) expressed NR4A3 by IHC, with strong (89%) or moderate (3%) nuclear staining, yielding a sensitivity of 92%. Recently, we discovered the recurrent genomic rearrangement [t(4;9)(q13;q31)] enabling upregulation of the transcription factor Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) through enhancer hijacking as the oncogenic driver event in acinic cell carcinoma (AciCC) of the salivary glands. National Library of Medicine Research activities. Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands. 1 Most of these tumors occur in the parotid gland. Molecular patterns in salivary duct carcinoma identify prognostic subgroups. Similarly, all MEC (20/20), SDC (20/20) and AdCC (10/10) were negative for NR4A3 by IHC, as were most PA (18/20; 15%) and PAC (18/20; 5%). The recently described HTN3-MSANTD3 gene fusion was observed in 4 of 49 (8%) evaluable AciCCs, all with nuclear NR4A3 immunostaining. Bethesda, MD 20894, Copyright Oncogenic orphan nuclear receptor NR4A3 interacts and cooperates with MYB in acinic cell carcinoma David Y. Lee, Kathryn J. Brayer, Yoshitsugu Mitani , Eric A. Burns, Pulivarthi H. Rao, Diana Bell , Michelle D. Williams , Renata Ferrarotto , Kristen B. Pytynia , Adel K. El-Naggar , Scott A. Ness Evaluation of NR4A3 immunohistochemistry (IHC) and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma John M. Skaugen MD Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. 8600 Rockville Pike The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. Source data are provided as a Source Data file - "Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands" Fig. Detailed Epub 2020 May 19. Background: Acinic cell carcinoma (AcCC) is diagnostically challenging on fine-needle aspiration because it can mimic several other neoplasms or even normal acinar tissue. Acinic cell carcinoma (AcCC) is a morphologically distinctive salivary gland malignancy often associated with chromosome rearrangements leading to overexpression of the NR4A3 transcription factor. Am J Surg Pathol. Acinic cell carcinoma is the third most common malignant form of salivary gland cancer. Appl Immunohistochem Mol Morphol. Nuclear NR4A3 immunostaining was a highly specific (100%) and sensitive (98%) marker for AciCC with only 1 negative case, whereas NR4A3 FISH was less sensitive (84%). Would you like email updates of new search results? We conclude that NR4A3 is upregulated through enhancer hijacking and has important oncogenic functions in AciCC. Zhonghua Bing Li Xue Za Zhi. The disease presents as a slow growing mass, associated with pain or tenderness in 50% of the cases. Importantly, all SC were negative for NR4A3 IHC, with no staining in 28/30 cases and weak focal staining, in < 5% of cells, in 2/30 (7%). Cancers (Basel). Acinic cell carcinoma of the salivary gland (ACC-SG) is characterized by a recurrent chromosomal rearrangement (t(4; 9)(q13; q31)) that upregulates the transcription factor NR4A3. Acinic cell carcinoma (AciCC) harbors a recurrent t(4;9)(q13;q31) translocation, which leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3). Acinic cell carcinoma is the third most common malignant form of salivary gland cancer. In summary, NR4A3 immunostaining is a highly specific and sensitive marker for AciCC, which may be especially valuable in cases with high-grade transformation and in "zymogen granule"-poor examples within the differential diagnostic spectrum of AciCC and MASC. [Expression of NR4A3/NOR-1 in acinic cell carcinoma of the salivary gland]. This site needs JavaScript to work properly. Accessibility Research fields. COVID-19 is an emerging, rapidly evolving situation. NOR-1 distinguishes acinic cell carcinoma from its mimics on fine-needle aspiration biopsy specimens. Nuclear NR4A3 immunostaining is a specific and sensitive novel marker for acinic cell carcinoma of the salivary glands Am J Surg Pathol , 43 ( 2019 ) , pp. Acinic cell carcinoma (AciCC) harbors a recurrent t(4;9)(q13;q31) translocation, which leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3). Oncogenic Orphan Nuclear Receptor NR4A3 Interacts and Cooperates with MYB in Acinic Cell Carcinoma. Nuclear NR4A2 (Nurr1) Immunostaining is a Novel Marker for Acinic Cell Carcinoma of the Salivary Glands Lacking the Classic NR4A3 (NOR-1) Upregulation. Nuclear NR4A2 (Nurr1) Immunostaining is a Novel Marker for Acinic Cell Carcinoma of the Salivary Glands Lacking the Classic NR4A3 (NOR-1) Upregulation. 2021 Feb;19(2):180-191. doi: 10.1158/1541-7786.MCR-20-0707. [Expression of NR4A3/NOR-1 in acinic cell carcinoma of the salivary gland]. Acinic cell carcinoma (AciCC) harbors a recurrent t(4;9)(q13;q31) translocation, which leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3). Accessibility However, little is known about how NR4A3 contributes to AcCC biology. 2018 Feb;42(2):e11-e27. Previous work on tissue microarrays suggests that NR4A3 immunohistochemistry (IHC) may be useful in the diagnosis of AciCC. 2019 Sep;43(9):1264-1272. doi: 10.1097/PAS.0000000000001279. Inventions. About. Coronavirus: Find the latest articles and preprints Sign in or create an account. Prevention and treatment information (HHS). 2020 Aug 27;12(9):2433. doi: 10.3390/cancers12092433. Please enable it to take advantage of the complete set of features! The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer. Almost 17 percent of the primary salivary gland carcinoma is related to the Acinic Cell Carcinoma. Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands Buy Article: $62.00 + tax ( Refund Policy ) 5 Analysis of enhancer activity in a genomic region shared by AciCCs with t(4;9)(q13;q31) rearrangement. doi: 10.1097/PAS.0000000000000980. [Expression of NR4A3/NOR-1 in acinic cell carcinoma of the salivary gland]. Cheng K, Wang X, Wei X, Ma J, Xia QY, Shi QL, Zhou XJ, Rao Q. Zhonghua Bing Li Xue Za Zhi. Epub 2020 Oct 26. Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of … 2020 Jun;14(2):562-569. doi: 10.1007/s12105-019-01054-w. Epub 2019 Jul 30. Privacy, Help Keywords: Abstract: Acinic cell carcinoma (AcCC) is a morphologically distinctive salivary gland malignancy often associated with chromosome rearrangements leading to overexpression of the NR4A3 transcription factor. 2020 Nov 8;49(11):1142-1146. doi: 10.3760/cma.j.cn112151-20200224-00127. 2020 Aug;102:1-6. doi: 10.1016/j.humpath.2020.05.001. Epub 2020 Oct 26. However, little is known about how NR4A3 contributes to AcCC biology. Often appears pseudoencapsulated. Abstract. Nuclear NR4A2 (Nurr1) Immunostaining is a Novel Marker for Acinic Cell Carcinoma of the Salivary Glands Lacking the Classic NR4A3 (NOR-1) Upregulation. 2020 Oct;33(10):1896-1909. doi: 10.1038/s41379-020-0576-2. Am J Surg Pathol. Head Neck Pathol. Epub 2020 May 26.
Item Not Showing Up In Catalog Animal Crossing, Heathrow To Bangkok Flight Tracker, Protective Custody Urban Dictionary, Dave From Friends, Arduino Radar Detector, Vitamin D3 50 Mcg 2,000 Iu Side Effects, Jamieson Vitamins Where To Buy, Ashland Crime Wave, Vitamin B12 Absorption Terminal Ileum,