This iron is transported by transferrin, and then stored in the liver, spleen and bone marrow. 500mcg: I recommend 500mcg, but taking sl B12 2500mcg will also lower a factor in heart disease, called homocysteine. Vitamin B12 Binding Capacity Unsaturated (Transcobalamin), binds and transports vitamin B12 in the circulation. Note: Patient should fast for 12 – 15 hours prior to collection. This test helps your health care provider know how well that protein can carry iron in your blood. Iron moves through the blood attached to a protein called transferrin. In order to diagnose abnormal total iron binding capacity, we could: Research the topic; Find a doctor with the time; Use a diagnostic computer system. The term low transferrin it refers to the decrease of the transferrin glycoprotein in the bloodstream. Vitamin B12 deficiency is defined by low levels of stored B12 in the body that can result in anemia, a lower-than-normal number of red blood cells. Synonyms. Total iron binding capacity (TIBC) is a blood test that shows if there is too much or too little iron in the blood. Spin down and send 1 mL of serum refrigerated in a plastic vial. Aliases Other names that describe the test. Total iron binding capacity (TIBC) is a blood test to see if you have too much or too little iron in your blood. The process is … Transferrin is a protein responsible for taking iron consumed daily after being absorbed by the intestine. Vitamin B12 supplements should not be administered within 72 hours of drawing blood for this test. Reference Values. A Vitamin B12 Blood Test, Unsaturated Binding Capacity is a differential diagnosis of polycythemia vera from secondary/relative polycythemias; evaluate macrocytic/megaloblastic anemia; diagnose congenital absence of transcobalamin II or cobalophilin (transcobalamin I and III) Vitamin B12 is available only in animal foods (meat and dairy products) or yeast extracts (such as brewer's yeast). Draw blood in a plain, red-top tube(s). Diagnosis is usually a complex process due to the sheer number of possible causes and related symptoms. This test helps measure the ability of a protein called transferrin to carry iron in the blood. Increased concentrations are associated with patients with myeloproliferative disorders. Send thanks to the doctor A 38-year-old member asked: Low mean cellular volume (MCV) Low ferritin; Low serum iron (FE) High transferrin or total iron-binding capacity (TIBC) Low iron saturation; The peripheral smear or blood slide may show small, oval-shaped cells with pale centers. Vitamin B12 deficiency can develop for the following reasons: 800 – 2600 pg/mL Interpretive Information: Vitamin B12 Binding Capacity. Vitamin B12 Deficiency Causes. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map. This assay measures the unsaturated binding capacity of serum for Vitamin B12. If vitamin B12 deficiency has been diagnosed, the next step is to determine what the underlying causes are, before beginning an appropriate treatment. In severe iron deficiency, the white blood count (WBC) may be low and the platelet count may be high or low. Vitamin B12 Binding Capacity: 2171-7 * Component test codes cannot be used to order tests. (Serum gel tube is acceptable.) Iron is carried in the blood attached to the protein transferrin.